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The Role of ADME Studies in Drug Discovery

ADME stands for Absorption, Distribution, Metabolism and Excretion. These are the four steps involved in pharmacokinetic studies which are designed to investigate how a drug compound is processed within the body of a living organism.

Oftentimes, toxicology tests also form a part of the ADME studies resulting in the abbreviation to be modified as ADMET.

Note that scientists use Lipinski’s rule of five and Verber’s rules to determine the pharmacokinetic properties of the drug.

Steps of ADME Explained:

1. Absorption

2. Distribution

3. Metabolism

4. Excretion

Role of ADME in Drug Discovery:

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